Scientific Program

Venue: Sutton Place
955 Bay Street
Toronto, M5S 2A2
Wellesley Room

Wednesday, November 12, 2008

• 18:00 – 20:00 Registration and Cocktails


• 20:00 – 20:30 Welcome (Yaacov Ben-David)

Thursday, November 13, 2008

• 7:30- 8:30 Breakfast (Royal Sutton Salons B and C)

Lectures: 08:30 – 17:30 All lectures take place in Royal Sutton Salon A

Session I: Expression and replication I
Chairs: Hung Fan
Maribeth Eiden

• 08:30 – 08:55 Laura Levy
  Unique Mutational Changes in the FeLV-945 Surface Glycoprotein (SU) Increase the Efficiency of Binding to the FeLV-A Receptor


• 08:55 – 09:20 Jonathan Stoye
  Evolutionary Interplay Between Fv1 and MLV


• 09:20 – 09:45 Christine Kozak
  Novel Fv1 Restriction Phenotypes and Sequence Variants in African Pygmy Mice and Evidence for Positive Selection of the Fv1 Gene in the Genus Mus


• 09:45 – 10:30 Coffee break (Royal Sutton Salons B and C)

Session II: Expression and replication II
Chairs: Karen Beemon
Carolyn Wilson

• 10:30 – 10:55 Frederick Arnaud
  Bst2/Tetherin Expression in the Reproductive Tract of the Domestic Sheep Blocks enJSRVs Virus Particle Release and is Under the Control of Interferon tau.


• 10:55 – 11:20 Benoit Barbeau
  Antisense Transcription in Human T-cell Leukemia Viruses and their Encoded Proteins
  


• 11:20 – 11:45 Eric Rassart
  Inhibition of Cas-Br-E Murine Leukemia Virus Replication Using Mutagenic Oligonucleotides Targeting the Integrase Coding Sequence
  


• 11:45 – 12:10 Brian Willett
  The virus-receptor interaction and the pathogenicity of the feline lentiviruses
  


• 12:10 – 13:30 Lunch (Royal Sutton Salons B and C)
  

Session III: Endogenous retroviruses
Chairs: Jonathan Stoye
Jaquelin Dudley

• 13:30 – 13:55 Leonard Evans
  The Mobilization of Endogenous Retroviruses in Mice after Infection with Exogenous Retroviruses.


• 13:55 – 14:20 Carolyn Wilson
  Residues Adjacent to and Including the Putative Proteolytic Cleavage Signal Influence Infectivity and Human Cell Tropism of Porcine Endogenous Retrovirus.
  


• 14:20 – 14:45 Massimo Palmarini
  Retrovirus Integrations Reveal the History of Migrations and Worldwide Population Structure of the Domestic Sheep
  


• 14:45- 15:20 Coffee break (Royal Sutton Salons B and C)

Session IV: Pathogenesis I (Friend Virus)
Chairs: Sandra Ruscetti
Marc Sitbon

• 15: 20 – 15:45 Yaacov Ben-David
  Enrichment of Sca-1 Positive Hematopoietic Progenitors in Polycythemic MICE Inhibits Leukemogenesis Induced by Friend Virus.


• 15:45 – 16:10 Robert Paulson
  Friend Virus Utilizes the BMP4 Dependent Stress Erythropoiesis Pathway to Induce Erythroleukemia in Mice.


• 16:10 – 16:35 Pamela Hankey
  Stat3 Promotes the Development of Friend Erythroleukemia by Upregulating Pu.1 Expression and Suppressing Erythroid Differentiation.
  


• 16:35 – 17:00 Sandra Ruscetti
  Neurodegeneration Caused by a Friend MuLV Variant is Associated With Vascular and Inflammatory Changes and Can Be Inhibited by Blocking Microglia Activation


• Dinner break (on your own)


• 20:00 – 22:00 Poster session (Royal Sutton Salons B and C)

Friday November 14, 2008

• 07:30-08:30 Breakfast (Royal Sutton Salons B and C)

Lectures: 8:30-12:00 Royal Sutton Salon A

Session V: Pathogenesis II (HTLV and Foamy Virus)
Chairs Kathryn Radke
Massimo Palmarini

• 08:30 – 08:55 Gerold Feuer
  HTLV-1 Infection of Humanized NOD/SCID Mice Recapitulates Adult T Cell Leulemia/Lymphoma (ATLL) Development


• 08:55 – 08:20 Lindsey Crawford
  Role of HBZ in HTLV-1 Leukemogenesis in Humanized SCID Mice
  


• 09:20 – 09:45 Maxine Linial
  Foamy virus transmission and genetic stability


• 09:45 – 10:20 Coffee break (Royal Sutton Salons B and C)

Session VI: Pathogenesis III (MMTV)
Chairs: Paul Neiman
Andrew Mason

• 10: 20 – 10:45 Andrew Mason
  Mouse Mammary Tumor Virus is Necessary to Trigger Autoimmune Biliary Disease in the NOD.c3c4 Mouse Model of Primary Biliary Cirrhosis


• 10:45 – 11:10 Jaquelin Dudley
  MMTV Encodes a Functional Nuclear Signal Peptide by Signal Peptidase Cleavage of Rem or Env Proteins


• 11:10 – 11:35 Susan Ross
  Expression of Murine APOBEC3 Alleles in Different Mouse Strains and Their Effect on Mouse Mammary Tumor Virus Infection


• 11:35 – 12:00 Beatriz Pogo
  The MMTV-like Virus Found in Human Breast Cancer.


• 12:00 – 13:00 Lunch (Royal Sutton Salons B and C)


• 13:15 – 22:00 Departure to Niagara Falls

Saturday November 15, 2008

• 07:30 - 08:30 Breakfast (Royal Sutton Salons B and C)

Lectures: 08:30-16:30 Royal Sutton Salon A

Session VII: Viral Entry I
Chairs: Laura Levy
Mauro Pistello

• 08:30 – 08:55 Lorraine Albritton
  Catherpsins Influence Fusion By Acting On The Virion And Not The Host Cell In Moloney MLV Infection.


• 08:55 – 09:20 Maribeth Eiden
  Gammaretroviruses as Emerging Infections: Insights into the Cell Surface Protein, PiT1 That Facilitates Virus Entry.
  


• 09:20 – 09:45 Kathryn Jones
  Human T-cell lymphotropic Virus Type 1 (HTLV-1) SU Uses Molecular Mimicry of the Neuropilin-1 Ligand VEGF-A165 To Enter Target Cells Via HSPGs and Neuropilin-1


• 09:45 – 10:10 Marc Sitbon
  Interaction of the HTLV, STLV-3 and BLV Envelope Receptor Binding Domains (RBD) with their Cellular Receptors and Impact on Cell Metabolism.


• 10:10 – 10:45 Coffee break (Royal Sutton Salons B and C)

Session VIII: Viral entry II
Chairs: Lorraine Albritton
Kathryn Jones

• 10:45 – 11:10 Mauro Pistello
  Evolution In Vivo of Envelope Glycoprotein of Feline Immunodeficiency Virus Modifies Susceptibility to Neutralization and Virus Receptor Interaction


• 11:10 – 11:35 Chetankumar Tailor
  Enhanced Alternative Splicing of the Subgroup C feline Leukemia Virus Receptor (FLVCR1) Gene as a Major Contributing Factor for the Anemia in Diamond Blackfan Anemia.


• 11:35 – 12:00 Shan-Lu Liu
  Mechanisms of PH-Dependent Fusion by Oncogenic Sheep Retrovirus Envelope Proteins


• 12:00 - 13:30 Lunch (Royal Sutton Salons B and C)

Session IX: Pathogenesis IV (Oncogenic and Immunodeficiency Retroviruses)
Chairs: William Green
Eric Rassart

• 13:30 – 13:55 Hung Fan
  In Vitro Transformation of Primary Rat and Sheep Type II Pneumocytes and MDCK Epithelial Cells by Jaagsiekte Sheep Retrovirus.


• 13:55 – 14:20 Beemon Karen
  Role of bic (miR-155) in Avian Leukosis Virus-induced Lymphomas


• 14:20 – 14:45 Monica Stewart
  MLV Targeting of thr JDP2 Locus in Lymphoma Progression : Expression of Truncated Isoforms and Repression of the Wild-Type Allele Suggest a Tumour Suppressor Functio


• 14:45 - 15:20 Coffee break (Royal Sutton Salons B and C)


• 15:20 – 15:45 James Neil
  The Runx Genes Regulate Growth Arrest, Senescence and Survival
  


• 15:45 – 16:05 Naomi Rosenberg
  Functional B-Cell Precursor Development Influences Susceptibility to Abelson Virus
  


• 16:05 – 16:30 William Green
  The Programmed Death-1 and Interleukin-10 Pathways Play a Down-Modulatory Role in LP-BM5 Retrovirus-Induced Murine Immunodeficiency Syndrome.
  


• 16:30 - 16:55 Lionel Berthoux
  Proteasome-dependent restriction of retroviruses by TRIM5α and MDM2.
  


• Final Remarks and Closing


• 19:00 – 24:00 Banquet (Stop 33 – 33rd floor of the Sutton Place)